Specificity
MON I-3 is specific for human PAI-1. No cross-reactivity is observed with PAI-2 as tested by ELISA andimmunoblotting. No reactivity is observed with any other human plasma protein when tested byimmunoblotting.
Immunogen
Partially purified human PAI-1
Positive Species Reactivity
Human
Negative Species Reactivity
Not determined
Epitope Specificity
MON I-3 binds to an epitope consisting of amino acids 235-283
Unit Size
200 µL: Cat. No. MON I-3-021 mL: Cat. No. MON I-3-11 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Protein A/G purified (from culture supernatant)
Solvent
0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Plasminogen activator inhibitor-1 (PAI-1) is the principal inhibitor of urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA). It belongs to the group of serpins (serine protease inhibitors). Elevated tumor and/or plasma levels of PAI-1 are associated with poor prognosis in many types of cancer.
Other Info
This product is not for further manufacture.
