Specificity
HYB 213-06 reacts with gp-340 also known as salivary scavenger and agglutinin.
Immunogen
Native gp-340 purified from bronchoalveolar lavage fluid from patients with pulmonary alveolar proteinosis.
Positive Species Reactivity
Human
Negative Species Reactivity
Not determined
Epitope Specificity
Protein chain (1)
Unit Size
200 µL: Cat. No. HYB 213-06-021 mL: Cat. No. HYB 213-06-11 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Protein A/G purified (from culture supernatant)
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Glycoprotein (gp)-340 is member of the scavenger receptor superfamily and has been identified as a putative SP-D receptor. Gp-340 has been shown to bind SP-D in a calcium-dependent manner through a protein-protein interaction. Like SP-D, gp-340 is found in the lungs and immunohistochemistry shows high expression in alveolar macrophages. An identical protein, salivary agglutinin, is present in saliva (1, 2, 3) and both gp-340 and salivary agglutinin are encoded by the gene DMBT1.
