Specificity
BTE 002-04 is specific for for native PICP from amniotic fluid.
Immunogen
PICP purified from second trimester amniotic fluid by affinity chromatography
Positive Species Reactivity
Human
Negative Species Reactivity
Not determined
Epitope Specificity
Not determined
Unit Size
200 µL: Cat. No. BTE 002-04-021 mL: Cat. No. BTE 002-04-11 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
protein A/G purified (from culture supernatant)
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Collagen type I is present in soft connective tissue and bone where it represents approximately 90% ofthe organic matrix. Collagen type I is produced from procollagen when two teloterminal propeptides aredigested from the precursor and released into the circulation. The propeptide levels can be measured inserum as indicators of collagen production. Elevated values of these propeptides in serum are found inpatients with various bone metabolism defects. Procollagen type I C-terminal propeptide (PICP) has amolecular weight of approximately 100 kDa and the normal range in serum is 100-300μg/ml.
