Specificity
ABS 062-14 is specific for human NGAL (neutrophil gelatinase-associated lipocalin).
Immunogen
Human recombinant NGAL coupled to carrier
Positive Species Reactivity
Human
Negative Species Reactivity
Not determined
Epitope Specificity
Differs from those of HYB 211-01, the ABS 038 series of antibodies and ABS 062-33.
Unit Size
50 µL: Cat. No. ABS 062-14B-0051 mg/mL +/- 15%. See Certificate of Analysis for details.
Solvent
0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15mM sodium azide
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Neutrophil gelatinase-associated lipocalin (NGAL; also called lipocalin 2, siderocalin and neutrophillipocalin) is a member of the lipocalin family of proteins which bind and transport small lipophilicmolecules. NGAL is released by activated neutrophils and occurs as 25-kDa glycosylated single proteinchain monomers, which form dimers and small amounts of higher oligomers, as well as complexes withmatrix metalloproteinase 9 (MMP-9; gelatinase B). Low level expression of NGAL in a variety of epitheliamay be increased in inflammation or cancers. Expression of NGAL in the kidney is dramatically increasedby acute kidney injury.
