Specificity
ABS 061-09 binds human glucagon. Cross-reacts less than 5% with oxyntomodulin.
Immunogen
Synthetic full length oxyntomodulin coupled to carrier.
Positive Species Reactivity
Human, Rat, Pig
Negative Species Reactivity
Not determined
Gene ID
2641, 24952, 397595
Epitope Specificity
The epitope lies within the C-terminal region of glucagon.
Unit Size
200 µL: Cat. No. ABS 061-09-021 mL: Cat. No. ABS 061-09-11 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
protein A/G purified (from culture supernatant)
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Glucagon is a peptide hormone of 29 amino-acid residues produced by the alpha cells of the pancreaticislets. Its effect is to raise blood sugar as a stress hormone and counter-regulatory hormone for insulin. Itis produced by cell-type-specific processing of proglucagon, which in the alpha cells is split to formglicentin-related pancreatic polypeptide, glucagon and major proglucagon fragment, while the sameprecursor is split to form glicentin, oxyntomodulin (C-terminally extended glucagon-37), GLP-1 and GLP-2in the L cells of the intestinal mucosa.
