Specificity
ABS 059-20 is specific for human oxyntomodulin. Cross-reacts fully with glucagon.
Immunogen
Synthetic full length oxyntomodulin coupled to carrier.
Positive Species Reactivity
Human
Negative Species Reactivity
Not determined
Epitope Specificity
ABS 059-20 has a different epitope specificity than ABS 064-46 and ABS 064-23.
Unit Size
200 µL: Cat. No. ABS 059-20-021 mL: Cat. No. ABS 059-20-11 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Protein A/G purified (from culture supernatant)
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
2-8ºC without exposure to light. No precautions necessary during handling.
Target
Oxyntomodulin is a peptide hormone of 37 amino-acid residues (29-amino acid sequence of glucagon, with an 8-amino acid carboxy-terminal extension) produced by the L cells of the gut. It modulates gastric acid secretion from the oxyntic cells of the stomach, inhibits appetite and has glucose lowering effects. Oxyntomodulin is produced by cell-type-specific processing of proglucagon that forms as well glicentin, GLP-1 and GLP-2 in the L cells of the intestinal mucosa.
