Specificity
ABS 038-15 binds human NGAL (neutrophil gelatinase-associated lipocalin).
Immunogen
Recombinant human NGAL
Positive Species Reactivity
Human
Negative Species Reactivity
Dog, Pig, Mouse, Rat
Epitope Specificity
Differs from those of HYB 211, ABS 038 and the ABS 062 series of antibodies.
Unit Size
50 µL: Cat. No. ABS 038-15B-0051 mg/mL +/- 15%. See Certificate of Analysis for details.
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Neutrophil gelatinase-associated lipocalin (NGAL; also called lipocalin 2, siderocalin and neutrophillipocalin) is a member of the lipocalin family of proteins which bind and transport small lipophilicmolecules. NGAL is released by activated neutrophils and occurs as 25-kDa glycosylated single proteinchain monomers, which form dimers and small amounts of higher oligomers, as well as complexes withmatrix metalloproteinase 9 (MMP-9; gelatinase B). Low level expression of NGAL in a variety of epitheliamay be increased in inflammation or cancers. Expression of NGAL in the kidney is dramatically increasedby acute kidney injury.
