Specificity
ABS 038-15 binds human NGAL (neutrophil gelatinase-associated lipocalin).
Immunogen
Recombinant human NGAL
Positive Species Reactivity
Human
Negative Species Reactivity
Dog, Pig, Mouse, Rat
Epitope Specificity
Differs from those of HYB 211 and the ABS 062 series of antibodies.
Unit Size
200 µL: Cat. No. ABS 038-15-021 mL: Cat. No. ABS 038-15-11 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Protein A/G purified (from culture supernatant)
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Neutrophil gelatinase-associated lipocalin (NGAL; also called lipocalin 2, siderocalin and neutrophil lipocalin) is a member of the lipocalin family of proteins which bind and transport small lipophilic molecules. NGAL is released by activated neutrophils and occurs as 25-kDa glycosylated single protein chain monomers, which form dimers and small amounts of higher oligomers, as well as complexes with matrix metalloproteinase 9 (MMP-9; gelatinase B). Low level expression of NGAL in a variety of epithelia may be increased in inflammation or cancers. Expression of NGAL in the kidney is dramatically increased by acute kidney injury.
