Specificity
ABS 038-14 binds human NGAL (neutrophil gelatinase-associated lipocalin).
Immunogen
Recombinant human NGAL
Positive Species Reactivity
Human, Pig, Dog
Negative Species Reactivity
Mouse, Rat
Gene ID
3934, 100153501, 491320
Epitope Specificity
Differs from those of HYB 211-01, -02, ABS 038-04, -15, -26 and the ABS 062 series of antibodies.
Unit Size
50 µL: Cat. No. ABS 038-14B-0051 mg/mL +/- 15%. See Certificate of Analysis for details.
Solvent
0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15mM sodium azide
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Neutrophil gelatinase-associated lipocalin (NGAL; also called lipocalin 2, siderocalin and neutrophil lipocalin) is a member of the lipocalin family of proteins which bind and transport small lipophilic molecules. NGAL is released by activated neutrophils and occurs as 25-kDa glycosylated single protein chain monomers, which form dimers and small amounts of higher oligomers, as well as complexes with matrix metalloproteinase 9 (MMP-9; gelatinase B). Low level expression of NGAL in a variety of epithelia may be increased in inflammation or cancers. Expression of NGAL in the kidney is dramatically increased by acute kidney injury.
