Specificity
ABS 038-14 binds human NGAL (neutrophil gelatinase-associated lipocalin).
Immunogen
Recombinant human NGAL
Positive Species Reactivity
Human, Pig, Dog
Negative Species Reactivity
Mouse, Rat
Gene ID
3934, 100153501, 491320
Epitope Specificity
Differs from those of HYB 211-01, -02, ABS 038-04, -15, -26 and the ABS 062 series of antibodies.
Unit Size
200 µL: Cat. No. ABS 038-14-021 mL: Cat. No. ABS 038-14-11 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Protein A/G purified (from culture supernatant)
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Neutrophil gelatinase-associated lipocalin (NGAL; also called lipocalin 2, siderocalin and neutrophillipocalin) is a member of the lipocalin family of proteins which bind and transport small lipophilicmolecules. NGAL is released by activated neutrophils and occurs as 25-kDa glycosylated single proteinchain monomers, which form dimers and small amounts of higher oligomers, as well as complexes withmatrix metalloproteinase 9 (MMP-9; gelatinase B). Low level expression of NGAL in a variety of epitheliamay be increased in inflammation or cancers. Expression of NGAL in the kidney is dramatically increasedby acute kidney injury.
