Specificity
ABS 033-04 binds the free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide and shows <0.2% cross-reactivity="" with="" glp-1(1-37),="" glp-1(9-36)amide,="" glucagon,="" human="" gip="" and="" exendin-4.="" cross-reacts="" approximately="" 1%="" with="" human="">
Immunogen
Synthetic GLP-1(7-17)
Positive Species Reactivity
Mammalia
Negative Species Reactivity
Not determined
Epitope Specificity
Free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide.
Unit Size
200 µL: Cat. No. ABS 033-04-021 mL: Cat. No. ABS 033-04-11 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Protein A/G purified (from culture supernatant)
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Glucagon-like peptide 1(7-36)amide (GLP-1(7-36)amide) is the principal active form of GLP-1, the other being GLP-1(7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.
