Specificity
ABS 030-06 binds human full length pancreatic polypeptide. Cross-reactivity with NPY and PYY was<>
Immunogen
Synthetic human PP
Positive Species Reactivity
Human
Negative Species Reactivity
Not determined
Epitope Specificity
Not determined
Unit Size
200 µL: Cat. No. ABS 030-06-021 mL: Cat. No. ABS 030-06-11 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Protein A/G purified (from culture supernatant)
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Pancreatic polypeptide (PP) is a 36 amino acid residue peptide with sequence and 3-D structuralhomology with NPY and PYY. PP is the least conserved of the three peptides and was the first to beidentified. It is almost exclusively expressed in the endocrine pancreas and released in response tocholinergic stimulation and food intake. PP has inhibitory effects on gall bladder secretion, intestinalmotility and pancreatic secretion. PP may serve as a marker for certain gut endocrine tumors includingcarcinoid tumors.
