Specificity
ABS 006-24 is specific for native human PAPP-A. Heat and SDS denatured PAPP-A is also recognized,but not acid treated PAPP-A.
Immunogen
Purified human PAPP-A
Positive Species Reactivity
Human
Negative Species Reactivity
Not determined
Epitope Specificity
The epitope of ABS 006-24 is different from BTE 004-09 and ABS 006-01. The epitope is located on thePAPP-A subunit of the heterotetramer.
Unit Size
200 µL: Cat. No. ABS 006-24-021 mL: Cat. No. ABS 006-24-11 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Protein A/G purified (from culture supernatant)
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease,PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which wasfirst discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunitsand two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screeningis used as a marker of Down’s syndrome (trisomy 21).
